Table 2 Comparison of the effects of D156844, AR42 and the combination of D156844 and AR42 treatments on the onset of body mass loss in SMNΔ7 SMA mice maintained on a PicoLab 20 diet. The D156844 data were previously published27.

From: The effect of coadministration of D156844 and AR42 (REC-2282) on the survival and motor phenotype of mice with spinal muscular atrophy

Treatment

Mean onset ± SE (d)

Minimum onset (d)

Maximum onset (d)

Median onset ± SE (d)

Source

D156844

17.7 ± 0.6

12.0

21.0

17.0 ± 0.6

27

AR42

13.0 ± 0.5

10.0

17.0

12.0 ± 0.6

this study

AR42 + D156844

18.6 ± 3.3

9.0

64.0

16.0 ± 1.2

this study

vehicle

11.4 ± 0.4

8.0

14.0

11.0 ± 0.5

this study

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