Table 4 Comparison of the effects of D156844, AR42 and the combination of D156844 and AR42 treatments on surface righting responses at PND07 and PND11 in SMNΔ7 SMA mice.

From: The effect of coadministration of D156844 and AR42 (REC-2282) on the survival and motor phenotype of mice with spinal muscular atrophy

  

D156844

AR42

D156844 + AR42

nonSMA

PND07

Vehicle

0.750 (0.386)

0 (1.000)

2.689 (0.101)

12.429 (< 0.001)

D156844

–

1.000 (0.317)

0.870 (0.351)

15.815 (< 0.001)

AR42

–

–

3.582 (0.058)

15.815 (< 0.001)

D156844 + AR42

–

–

–

12.429 (< 0.001)

PND11

vehicle

0.929 (0.315)

0.720 (0.788)

0.202 (0.653)

10.000 (0.002)

D156844

–

0.883 (0.347)

0.565 (0.452)

11.000 (< 0.001)

AR42

–

–

0.021 (0.884)

13.000 (< 0.001)

D156844 + AR42

–

–

-

11.000 (< 0.001)

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