Table 5 Comparison of the effects of D156844, AR42 and the combination of D156844 and AR42 treatments on successful movement responses at PND07, PND11 and PND14 in SMNΔ7 SMA mice.
D156844 | AR42 | D156844 + AR42 | nonSMA | ||
|---|---|---|---|---|---|
PND07 | Vehicle | 0.750 (0.386) | 0 (1.000) | 2.689 (0.101) | 12.429 (< 0.001) |
D156844 | – | 1.000 (0.317) | 0.870 (0.351) | 15.815 (< 0.001) | |
AR42 | – | – | 3.582 (0.058) | 15.815 (< 0.001) | |
D156844 + AR42 | – | – | – | 12.429 (< 0.001) | |
PND11 | Vehicle | 0.929 (0.315) | 0.720 (0.788) | 0.202 (0.653) | 10.000 (0.002) |
D156844 | – | 0.883 (0.347) | 0.565 (0.452) | 11.000 (< 0.001) | |
AR42 | – | – | 0.021 (0.884) | 13.000 (< 0.001) | |
D156844 + AR42 | – | – | – | 11.000 (< 0.001) | |
PND14 | Vehicle | 6.000 (0.014) | 5.000 (0.025) | 6.000 (0.014) | 5.000 (0.025) |
D156844 | – | 1.374 (0.241) | 8.461 (0.004) | 11.137 (< 0.001) | |
AR42 | – | – | 0.889 (0.346) | 4.726 (0.030) | |
D156844 + AR42 | 3.180 (0.075) |
