Fig. 3
Detection of related proteome in the plasma of patients with acne and healthy controls. A PCA revealed a clear difference between patients with acne and IR(n=40) and healthy controls with IR(n=11). B Individual molecular features associated with acne resulted in significantly upregulated and downregulated proteins in patients with IR (P < 0.05, FC ≥ 2 or ≤ 0.5). C Heatmap analysis showed expression levels and pathway enrichment of proteins in both patients with acne and IR and healthy controls with IR groups. D and E The difference in the clinical information of patients with acne in the insulin-resistant group compared to the healthy controls. F. PCA revealed a distinct difference between patients with acne without IR(n=50) and healthy controls without IR(n=19). G Individual molecular features associated with acne resulted in significantly upregulated and downregulated proteins in patients without IR (P < 0.05, FC ≥ 2 or ≤ 0.5). H Heatmap analysis showed expression levels and pathway enrichment of proteins in both patients with acne and healthy individuals without IR groups. I and J The difference in the clinical information of patients with acne in the non-insulin-resistant group compared to the healthy population (Dietary Categories: Light -1; Sweet-2; Greasy-3; Spicy-4; Mixed-5).
