Fig. 4
Plasma proteomic characterization of acne with or without IR. A Retrospective tissue analysis revealed molecular signatures associated with tissue loss in patients with acne with or without IR. B Statistical analysis of the clinical information revealed significant differences in gender(P =1.46E-3, Fisher’s exact test) between the two groups. C Statistical analysis of the clinical information revealed significant differences in testosterone levels (P =4.83E-3, Wilcoxon sign-rank test) between the two groups. D Pearson correlation analysis showed a significant positive correlation between T cells and the arachidonic acid metabolism pathway (Pearson’s R =0.45, P = 9.75E-4), and between T cells and prostaglandin signals(Pearson’s R =0.30,P = 0.36) in patients with acne without IR. E Pearson correlation analysis showed no significant positive correlation between T cells and the arachidonic acid metabolism pathway (Pearson’s R =0.15, P = 0.349), and between T cells and prostaglandin signals (Pearson’s R =0.27,P = 0.09) in patients with acne without IR in patients with acne with IR. F The representative characteristic molecules and molecules of the distinct pathways of tissue damage in patients with acne with or without IR.
