Table 1 Reduction conditions of ketone 10.
From: An improved synthesis of TRβ-selective thyromimetic GC-1
Entry | Reagent / sovlent | Time (h) | Temp | Yielda 11 / 12 (%) |
|---|---|---|---|---|
1 | NaBH4/EtOH | 24 | r.t. | 0/0 |
2 | NaBH4, AcOH/EtOH | 8 | 40 ℃ | 0/20b |
3 | NaBH4, CaCl2/EtOH | 10 | r.t. | 0/10b |
4 | NaBH4, LiCl/EtOH | 8 | r.t. | 0/50b |
5 | LiBH4 /THF | 6 | r.t. | 0/80 |
6 | B2H6/THF | 3 | 0 ℃-r.t. | complex |
7 | LiAlH4/THF | 4 | 0 ℃-r.t. | complex |
