Table 2 Compliance and adverse reactions of radiotherapy and chemotherapy.

From: Safety and efficacy of individualized modified total neoadjuvant therapy for low locally advanced rectal cancer

Characteristics

Neoadjuvant chemotherapy paradigm

P value

IC (n = 16)

CC (n = 20)

IC + CC (n = 26)

Neoadjuvant chemotherapy(mFOLFOX6) cycles

   

0.747

 > 1 to ≤ 4

7 (43.75)

7 (35.00)

8 (30.77)

 

 > 4 to ≤ 6

9 (56.25)

13 (65.00)

18 (69.23)

 

Adjuvant Chemotherapy cycles

   

0.531

0

0 (0.00)

2 (10.00)

2 (7.69)

 

 > 1 to ≤ 4

9 (56.25)

11 (55.00)

18 (69.23)

 

 > 4 to ≤ 6

7 (43.75)

7 (35.00)

6 (23.08)

 

Radiotherapy and chemotherapy toxicity grade

   

0.662

Gastrointestinal toxicity

    

0–1

13 (81.25)

15 (75.00)

18 (69.23)

 

2–3

3 (18.75)

5 (25.00)

8 (30.77)

 

Hematologic toxicity

   

0.323

0–1

14 (87.50)

14 (70.00)

17 (65.38)

 

2–3

2 (12.50)

6 (30.00)

9 (34.62)

 

Liver function impairment

   

0.879

0–1

15 (93.75)

17 (85.00)

23 (88.46)

 

2–3

1 (6.25)

3 (15.00)

3 (11.54)

 

Peripheral neurotoxicity

   

0.911

0–1

14 (87.50)

17 (85.00)

21 (80.77)

 

2–3

2 (12.50)

3 (15.00)

5 (19.23)

 

Skin toxicity

   

0.895

0–1

14 (87.50)

18 (90.00)

22 (84.62)

 

2–3

2 (12.50)

2 (10.00)

4 (15.38)

 
  1. Note: IC: Induction chemotherapy; CC: Consolidation chemotherapy; IC + CC: Induction + consolidation chemotherapy; mFOLFOX6: Modified FOLFOX6 regimen.