Table 1 Demographic and clinical characteristics of patients.
Characteristics | Total (n = 20) |
|---|---|
Age (year)* | 18 [11] |
Sex | |
Female | 11 (55) |
Male | 9 (45) |
Ethnicity | |
Hispanic/Latino | 13 (65) |
Non-Hispanic/Non-Latino | 7 (35) |
Race | |
Other | 12 (60) |
White | 5 (25) |
Asian | 2 (10) |
Native Hawaiian or Other Pacific Islander | 1 (5) |
Steroid treatment | |
No | 14 (70) |
Yes | 6 (30) |
Hematopoietic stem cell transplantation | |
No | 3 (15) |
Yes | 17 (85) |
Type of CAR T-cell agent | |
CD19/22 | 7 (35) |
CD19 | 12 (60) |
CD22 | 1 (5) |
Cytokine release syndrome grade | |
0 | 1 (5) |
1 | 11 (55) |
2 | 5 (25) |
3 | 2 (10) |
4 | 1 (5) |
Disease Burden | |
No detectable | 16 (80) |
Low (<5% bone marrow blasts) | 2 (10) |
High (≥5% bone marrow blasts) | 2 (10) |
Flow Cytometry | |
Lymphocytes percentage | 24.35 [18] |
Lymphocytes absolute count | 643 [490] |
CD4⁺ Recent Thymic Emigrants % | 17.15 [38.45] |
CD4⁺ Recent Thymic Emigrants Abs | 26.18 [82.10] |
Bone marrow blast | 12 [10.75] |
Bone marrow lymphocytes | 0.5 [0] |
CAR T-cell persistence (days) | 75.5 [99.5] |
Time Between Imaging and CAR (days) | 51 [107] |
Thymus volume (cm3)* | |
Before therapy | 4.52 [8.13] |
After therapy | 6.85 [20.58] |
Thymus transverse size | |
Before therapy | 65 [11.15] |
After therapy | 70 [11.25] |
