Fig. 1 | Scientific Reports

Fig. 1

From: The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner

Fig. 1The alternative text for this image may have been generated using AI.

Topical sodium dodecyl benzene sulfonate (SDBS) treatment attenuated MC903-induced Atopic dermatitis (AD)-like dermatitis. (A) The molecular structural formula of SDBS. (B) Schematic diagram of the timeline for the induction of the mouse MC903-induced AD-like model. (C) Representative images of clinical features of MC903-induced AD-like mice treated with ethanol or SDBS or desonide or tacrolimus at d 21. (D) Thicknesses of mouse ear lesions (mm) (left panel) and dermatitis severity scores of mouse lesions (right panel) at d 21. (E) Serum levels of total immunoglobulin E (IgE) in the MC903-induced AD-like mice treated with ethanol or SDBS or desonide or tacrolimus. (F) Representative images of histological sections of the skin stained with hematoxylin and eosin (H&E) (400×) at d 21 (left panel) and thickness of the epidermis (µm) (right panel). (G) Toluidine blue staining images of ethanol or SDBS or desonide or tacrolimus-treated skin tissue from MC903-induced AD-like mice to show the numbers of infiltrating mast cells. Right panel shows mast cell counts which was performed in 5 randomly selected bright high-power field (HPF) (400×). The data are presented as the mean ± standard error of the mean (n = 8). Statistically significant differences indicated as ####, p < 0.0001, ##, p < 0.01 compared to the Control/MC903 group; ****, p < 0.0001, ***, p < 0.001, *, p < 0.05 compared to the MC903 + Treatment/MC903 group.

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