Table 3 Distribution of AKR1C4 rs17134592 (C931G) genotypes in study participants and assessment of the risk of breast cancer.
Genetic model | Genotype or allele | Control (n = 310) n (%) | Case (n = 310) n (%) | p value | OR (95% CI) |
|---|---|---|---|---|---|
Additive model 1 (CG vs. CC) | CC | 185 (62.71) | 160 (60.15) | 0.54 (ns) | 1 (Ref.) |
CG | 110 (37.29) | 106 (39.85) | 1.11 (0.79 to 1.56) | ||
Additive model 2 (GG vs. CC) | CC | 185 (92.50) | 160 (78.43) | < 0.0001 (s) | 1 (Ref.) |
GG | 15 (7.50) | 44 (21.57) | 3.39 (1.80 to 6.50) | ||
Dominant model (CG + GG vs. CC) | CC | 185 (59.68) | 160 (51.61) | 0.05 (ns) | 1 (Ref.) |
CG + GG | 125 (40.32) | 150 (48.39) | 1.39 (1.01 to 1.91) | ||
Recessive model (GG vs. CC + CG) | CC + CG | 295 (95.16) | 266 (85.81) | < 0.0001 (s) | 1 (Ref.) |
GG | 15 (4.84) | 44 (14.19) | 3.25 (1.78 to 6.08) | ||
Allelic model (G vs. C) | C | 480 (77.42) | 426 (68.71) | 0.0007 (s) | 1 (Ref.) |
G | 140 (22.58) | 194 (31.29) | 1.56 (1.21 to 2.01) |
