Table 4 Frequency distribution of AKR1C4 rs17134592 (C931G) genotypes according to the menopausal status.
Menopausal status | Genetic model | Genotype/allele | Controls n (%) | Cases n (%) | OR (95% CI) | p value |
|---|---|---|---|---|---|---|
Pre-menopausal Controls 131 Case 110 | Additive Model 1 | CC | 77 (62.10) | 56 (57.73) | 1 (Ref.) | 0.58 (ns) |
CG | 47 (37.90) | 41 (42.27) | 1.20 (0.70 to 2.05) | |||
Additive Model 2 | CC | 77 (91.67) | 56 (81.16) | 1 (Ref.) | 0.09 (ns) | |
GG | 7 (8.33) | 13 (18.84) | 2.55 (0.99 to 6.49) | |||
Dominant Model | CC | 77 (58.78) | 56 (50.91) | 1 (Ref.) | 0.24 (ns) | |
CG + GG | 54 (41.22) | 54 (49.09) | 1.38 (0.83 to 2.30) | |||
Recessive Model | CC + CG | 124 (94.66) | 97 (88.18) | 1 (Ref.) | 0.10 (ns) | |
GG | 7 (5.34) | 13 (11.82) | 2.37 (0.97 to 6.07) | |||
Post-menopausal Controls 179 Cases 200 | Additive Model 1 | CC | 108 (63.16) | 104 (61.54) | 1 (Ref.) | 0.82 (ns) |
CG | 63 (36.84) | 65 (38.46) | 1.07 (0.70 to 1.64) | |||
Additive Model 2 | CC | 108 (93.10) | 104 (77.04) | 1 (Ref.) | 0.0004 (s) | |
GG | 8 (6.90) | 31 (22.96) | 4.02 (1.77 to 8.62) | |||
Dominant Model | CC | 108 (60.33) | 104 (52.00) | 1 (Ref.) | 0.12 (ns) | |
CG + GG | 71 (39.66) | 96 (48.00) | 1.40 (0.93 to 2.13) | |||
Recessive Model | CC + CG | 171 (95.53) | 169 (84.50) | 1 (Ref.) | 0.0006 (s) | |
GG | 8 (4.47) | 31 (15.50) | 3.92 (1.80 to 8.35) |
