Fig. 3 | Scientific Reports

Fig. 3

From: A preliminary bioinformatic screen to identify SRI SMC2 PSIP1 TLE4 and MSX1 as potential diagnostic and prognostic markers of osteoarthritis

Fig. 3

Selection and functional analysis of OA-related genes. Data were downloaded from the GEO database GSE179716 and GSE206848. 142 upregulated and 319 down-regulated genes commonly dysregulated in OA-affected chondrocytes (GSE179716) and synoviocytes (GSE206848) were selected and visualized by Venn diagram using FunRich (v3.1.3) (http://www.funrich.org/) software (A). Protein-protein interaction network visualized using STRING platform. Active interaction source: “Text-mining”, “Experiments”, “Databases”, “Co-expression”, “Neighborhood”, “Gene Fusion”, “Co-occurrence”. Minimum required interaction score: 0.4. Network analysis performed via Cytoscape 3.9.1. presenting average value of BetweennessCentrality, ClosenessCentrality, ClusteringCoefficient, and Degree calculated for each obtained network. Analysis of Fold change enrichment of Biological Processes and cellular components performed and visualized using FunRich (v3.1.3) (http://www.funrich.org/) software supported by Gene Ontology (GO) (http://geneontology.org/) (B).

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