Table 1 Biological pathways enriched by up-regulated genes in OA-affected tissue from the GSE179716 and the GSE206848 data sets. Analysis performed using platform FunRich. * p < 0.05; ** p < 0.005; *** p < 0.001.

Adherens junctions interactions

*

Alpha9 beta1 integrin signaling events

*

Arf6 downstream pathway

*

Arf6 signaling events

*

Arf6 trafficking events

*

Aurora A signaling

*

Aurora B signaling

*

Axon guidance

*

Beta1 integrin cell surface interactions

***

Beta3 integrin cell surface interactions

**

Cell cycle. mitotic

**

Cell-extracellular matrix interactions

*

Class I PI3K signaling events

*

Class I PI3K signaling events mediated by Akt

*

C-MYC pathway

*

Cyclin D associated events in G1

*

DNA replication

*

EGF receptor (ErbB1) signaling pathway

*

EGFR1

*

EGFR-dependent endothelin signaling events

*

Endothelins

**

Epithelial-to-mesenchymal transition

**

ErbB receptor signaling network

*

ErbB1 downstream signaling

*

FOXM1 transcription factor network

*

Gene expression

*

Glucocorticoid receptor regulatory network

*

Glypican 1 network

*

Glypican pathway

**

GMCSF-mediated signaling events

*

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

*

IFN-gamma pathway

*

IGF1 pathway

*

IL1-mediated signaling events

*

IL3-mediated signaling events

*

IL5-mediated signaling events

*

Insulin pathway

*

Integrin cell surface interactions

***

Integrin family cell surface interactions

***

Internalization of ErbB1

*

LKB1 signaling events

*

Metabolism of RNA

*

Mitotic M-M/G1 phases

*

mTOR signaling pathway

*

Muscle contraction

***

Olfactory signaling pathway

*

PAR1-mediated thrombin signaling events

*

PD-1 signaling

*

PDGF receptor signaling network

*

PDGFR-beta signaling pathway

*

Plasma membrane estrogen receptor signaling

**

Proteoglycan syndecan-mediated signaling events

**

Response to elevated platelet cytosolic Ca2+

**

S1P1 pathway

*

Signaling events mediated by focal adhesion kinase

*

Signaling events mediated by hepatocyte growth factor receptor (c-Met)

*

Signaling events mediated by VEGFR1 and VEGFR2

*

Smooth muscle contraction

***

Syndecan-1-mediated signaling events

*

Syndecan-2-mediated signaling events

**

Thrombin/protease-activated receptor (PAR) pathway

*

TRAIL signaling pathway

*

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

*

VEGF and VEGFR signaling network

*