Table 3 Selected genes presenting dysregulated mRNA level in OA-affected joint tissues - potential markers of osteoarthritis.
Gene | Protein | Note | mRNA level in OA vs. Control |
|---|---|---|---|
MSX1 | Msh Homeobox 1 | Muscle segment homeobox gene 1 | Upregulated |
TLE4 | Transducin-like enhancer of split protein 4 | Transcriptional corepressor, structural analog to the Drosophila protein Groucho | Upregulated |
PSIP1 | PC4 And SRSF1 interacting protein 1 | Lens epithelium-derived growth factor (LEDGF/p75) | Downregulated |
SMC2 | Structural maintenance of chromosomes 2 | Structural Maintenance Of Chromosomes (SMC) Family Member, Chromosome-Associated Protein E | Downregulated |
SRI | Sorcin | Soluble resistance-related calcium-binding protein | Downregulated |
