Table 1 Optimization conditions for the synthesis of 7aa.

From: A highly chemo- and regioselective synthesis of heterocyclic [3.3.3]propellanes via sequential multicomponent reactions in water

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Entry

Solvent

Temp. (oC)

Yieldb (%)

1

EtOH

rt

0

2

EtOH

78

20

3

MeCN

80

0

4

MeOH

64

0

5

Neat

rt

0

6

H2O

100

trace

7

H2O

rt

85

  1. aReagents and conditions: 1, 2, 6a (1 mmol), solvent (8 mL). b Isolated yield based on 7a.
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