Fig. 8

Establishment of a prognostic signature with the MCM6-related cell cycle genes. (A) The genes shared by modules related to different clinical features were identified using Venn diagram. (B) Forest plot shows the univariate regression analysis of OS for genes included in the prognostic signature. (C,D) K-M survival analysis shows the difference in survival between patients with different risk scores in the training (TCGA-LUAD) and validation groups (GSE42127). (E,F) The ROC analysis shows that risk scores of 6-gene signature had high predictive accuracy in the training (TCGA-LUAD) and validation groups (GSE42127). (G) A nomogram based on this risk score to predict the 1, 3, and 5-year overall survival for LUAD patients.