Table 4 Oxidative stress indexes in the liver of zebrafish fed diets with a conventional diet (CD), a high-fat diet (HFD), and an HFD supplemented with 2% Nannochloropsis oculate (HFD + NO) for 4 weeks (means ± SD). The letters of the difference in each row indicate significance. P < 0.05 was considered as significant.

From: Astaxanthin-rich Nannochloropsis oculata mitigates high-fat diet-induced liver dysfunction in zebrafish by modulating lipid metabolism and oxidative stress

Parameters

CD

HFD

HFD + NO

P-value

SOD (U/mg prot)

2.25 ± 0.13 a

1.75 ± 0.09 c

2.00 ± 0.05 b

< 0.001

CAT (U/mg prot)

6.35 ± 0.09 a

5.17 ± 0.12 c

6.14 ± 0.01 b

0.002

GPx (U/mg prot)

45.10 ± 1.13 a

25.22 ± 1.24 c

30.17 ± 1.11 b

0.001

GST (U/mg prot)

18.13 ± 0.75 a

25.10 ± 0.28 c

21.09 ± 0.23 b

0.002

GSH (nmol/mg prot)

35.15 ± 1.21 a

19.17 ± 2.11 c

25.12 ± 1.31 b

< 0.001

GSSG (nmol/mg prot)

21.15 ± 0.88 a

16.19 ± 0.73 c

18.12 ± 0.65 b

0.001

GR (mU/mg prot)

15.12 ± 0.65 a

6.10 ± 1.13 c

10.10 ± 1.05 b

< 0.001

MDA (nmol/mg prot)

2.70 ± 0.05 c

6.11 ± 0.07 a

4.15 ± 0.09 b

< 0.001

  1. SOD, Superoxide dismutase; CAT, Catalase; GPx, Glutathione peroxidase; GST, Glutathione S-transferases; GSH, Glutathione; GSSG, oxidized glutathione; GR, glutathione reductase; MDA, Malondialdehyde
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