Table 5 Serum enzymological indexes and lipid profiles of serum and liver zebrafish fed diets with a conventional diet (CD), a high-fat diet (HFD), and an HFD supplemented with 2% Nannochloropsis oculate (HFD + NO) for 4 weeks (means ± SD)

From: Astaxanthin-rich Nannochloropsis oculata mitigates high-fat diet-induced liver dysfunction in zebrafish by modulating lipid metabolism and oxidative stress

Parameters

CD

HFD

HFD + NO

P-value

Serum assay

AST(U/L)

179.11 ± 6.23c

271.12 ± 7.12 a

212.23 ± 3.22b

0.003

ALT(U/L)

4.15 ± 0.68c

8.70 ± 0.14 a

5.75 ± 0.32 b

0.001

GGT(U/L)

7.15 ± 0.25 c

11.24 ± 0.16 a

8.55 ± 0.12 b

< 0.001

ALP (U/L)

38.12 ± 1.10c

59.36 ± 1.22 a

45.11 ± 1.66 b

0.001

LDH(U/L)

191.22 ± 2.52c

224.31 ± 3.12 a

219.98 ± 1.72b

< 0.001

TG(mg/dL)

173.33 ± 5.64c

240.19 ± 9.42 a

210.13 ± 3.55b

< 0.001

TC(mg/dL)

75.11 ± 2.10c

128.32 ± 3.66 a

110.11 ± 1.8 b

0.002

Liver assay

TL (mg/g)

1.93 ± 0.07c

5.70 ± 0.12 a

3.10 ± 0.06 b

< 0.001

TC (µg/g)

125.1 ± 1.55c

165.72 ± 2.31a

136.15 ± 3.10b

0.001

FC (µg/g)

33.11 ± 1.20c

47.59 ± 1.28 a

40.03 ± 0.52 b

0.003

TG (µg/g)

39.75 ± 2.90c

83.69 ± 1.23 a

50.16 ± 2.01 b

< 0.001

  1. The letters of the difference in each row indicate significance. P < 0.05 was considered as significant.
  2. AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; GGT, Gamma-glutamyltransferase; ALP, Alkaline phosphatase; LDH, lactate dehydrogenase; TG, Total triglyceride; TC, Total cholesterol; FC, Fatty acids; TG, Triglyceride