Fig. 6

GSEA for GSE135917 between OSA group and Control group. (A) Mountain map summarising the four pathways that passed the significance threshold. For each pathway the normalised enrichment score (NES), adjusted P value (P adj) and false-discovery rate (FDR) are shown. (B–E) Running enrichment curves for the same pathways: Metabolism of Polyamines (B; NES = 2.996), Hedgehog Ligand Biogenesis (C; NES = 3.023), Auf1/Hnrnp D0 Binds and Destabilises mRNA (D; NES = 3.249) and Negative Regulation of NOTCH4 Signalling (E; NES = 3.500). The red line indicates the cumulative enrichment score across the ranked gene list; the lower barcode shows the position of leading-edge genes (red = up-regulated in OSA, blue = up-regulated in controls). The screening criteria of GSEA were adj. p < 0.05 and FDR value (q value) < 0.25, and the adj. p correction method was Benjamini-Hochberg (BH). GSEA Gene Set Enrichment Analysis.