Table 2 Result of GO and KEGG enrichment analysis for hmrdegs.

From: Polygenic insight identifies precision biomarkers decoding protein catabolism and autophagy pathways in obstructive sleep apnea

ONTOLOGY

ID

Description

GeneRatio

BgRatio

p value

p. adjust

q value

BP

GO:0062197

Cellular response to chemical stress

6/24

317/18,870

2.2357E − 06

0.00223696

0.00137612

BP

GO:0045862

Positive regulation of proteolysis

6/24

350/18,870

3.9591E − 06

0.00223696

0.00137612

BP

GO:0032436

Positive regulation of proteasomal ubiquitin-dependent protein catabolic process

4/24

93/18,870

5.4471E − 06

0.00223696

0.00137612

BP

GO:2,000,060

Positive regulation of ubiquitin-dependent protein catabolic process

4/24

113/18,870

1.181E − 05

0.00333926

0.00205423

BP

GO:1,901,800

Positive regulation of proteasomal protein catabolic process

4/24

117/18,870

1.3552E − 05

0.00333926

0.00205423

CC

GO:0016234

Inclusion body

3/24

71/19,886

8.3646E − 05

0.0124633

0.00783634

CC

GO:0005776

Autophagosome

3/24

116/19,886

0.00035796

0.02666797

0.01676757

CC

GO:0016235

Aggresome

2/24

35/19,886

0.00081062

0.04026078

0.02531409

MF

GO:0031625

Ubiquitin protein ligase binding

6/24

308/18,496

2.1231E − 06

0.00027308

0.00015794

MF

GO:0044389

Ubiquitin-like protein ligase binding

6/24

327/18,496

3.0008E − 06

0.00027308

0.00015794

MF

GO:0035259

Nuclear glucocorticoid receptor binding

2/24

12/18,496

0.00010566

0.00567707

0.00328344

MF

GO:0008429

Phosphatidylethanolamine binding

2/24

13/18,496

0.00012477

0.00567707

0.00328344

MF

GO:0140297

DNA-binding transcription factor binding

5/24

477/18,496

0.00031642

0.01026426

0.00593653

KEGG

hsa05418

Fluid shear stress and atherosclerosis

5/19

141/8875

9.1637E − 06

0.00113629

0.00093566

KEGG

hsa04621

NOD-like receptor signaling pathway

5/19

189/8875

3.7893E − 05

0.00234938

0.00193455

KEGG

hsa04137

Mitophagy—animal

4/19

105/8875

6.2543E − 05

0.00258512

0.00212866

KEGG

hsa04140

Autophagy—animal

4/19

169/8875

0.00039331

0.01219269

0.01003982

KEGG

hsa05131

Shigellosis

4/19

250/8875

0.00170627

0.04231559

0.0348439

  1. GO Gene Ontology, BP Biological Process, CC Cellular Component, MF Molecular Function, KEGG Kyoto Encyclopedia of Genes and Genomes, HMRDEGs Hypoxia and Mitophagy-Related Differentially Expressed Genes.
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