Table 1 Experimental validation of the calculated optimized formulation.

From: Surface functionalized albumin nanoparticles of palbociclib with amplified brain delivery for treating brain glioblastoma

Central composite design (CCD) optimization

Albumin concentration (mg) X1

Glutaraldehyde (%) X2

Particle size (nm) Y1

PDI Y2

Zeta potential (mV) Y3

Theoretical

129.16

4.73

138.69

0.21

17.7

Practical/experimental

130.00

5.00

167.57

0.25

16.2

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