Table 1 Baseline characteristics of participants by stroke status in NHANES and CHARLS.

From: Frailty index is positively associated with stroke risk in nationally representative cohorts from the united States and China

Characteristics

NHANES

CHARLS

Not Stroke

Stroke

P value

Not Stroke

Stroke

P value

Frailty index

0.13 ± 0.00

0.30 ± 0.00

< 0.001

0.10 ± 0.08

0.16 ± 0.12

< 0.001

Age (years)

46.42 ± 0.18

64.50 ± 0.42

< 0.001

57.53 ± 8.58

61.56 ± 9.26

< 0.001

Sex, n (%)

  

0.003

  

< 0.01

Female

27,712(51.84)

1141(56.27)

 

21,889(53.34)

1170(50.47)

 

Male

25,623(48.16)

1132(43.73)

 

19,148(46.66)

1148(49.53)

 

Marital status, n (%)

  

< 0.001

  

< 0.001

Married

31,792(63.50)

1143(55.53)

 

37,074(90.34)

2006(86.54)

 

Not married

21,053(36.50)

1107(44.47)

 

3963(9.66)

312(13.46)

 

Education, n (%)

  

< 0.001

  

< 0.001

Below high school

6199(5.72)

409(11.49)

 

27,305(66.60)

1744(75.24)

 

High school

20,090(35.05)

1039(47.41)

 

12,996(31.70)

558(24.07)

 

Above high school

26,968(59.24)

820(41.10)

 

699(1.70)

16(0.69)

 

Drinking status, n (%)

  

< 0.001

  

< 0.001

Never

47,195(90.06)

1970(87.65)

 

5570(18.14)

396(22.82)

 

Former

3220(4.97)

211(8.18)

 

962(3.13)

23(1.33)

 

Current

2920(4.97)

92(4.17)

 

24,169(78.72)

1316(75.85)

 

Smoking status, n (%)

  

< 0.001

  

< 0.001

Never

29,467(54.44)

932(42.00)

 

11,631(28.35)

686(29.63)

 

Former

12,819(24.44)

826(33.86)

 

4010(9.77)

292(12.61)

 

Current

11,004(21.12)

510(24.15)

 

25,383(61.87)

1337(57.75)

 

Body Mass Index (kg/m²)

28.79 ± 0.06

29.84 ± 0.20

< 0.001

23.49 ± 3.85

24.03 ± 3.94

< 0.001

Diabetes, n (%)

  

< 0.001

  

< 0.001

No

45,252(90.75)

1513(70.23)

 

36,701(89.56)

1936(83.52)

 

Yes

6576(9.25)

758(29.77)

 

4280(10.44)

382(16.48)

 

Hypertension, n (%)

  

< 0.001

  

< 0.001

No

31,745(64.47)

430(22.50)

 

27,571(67.24)

1076(46.50)

 

Yes

21,572(35.53)

1843(77.50)

 

13,431(32.76)

1238(53.50)

 

Hyperlipidemia, n (%)

  

< 0.001

  

< 0.001

No

17,007(32.44)

419(16.84)

 

28,526(69.88)

1427(61.75)

 

Yes

36,318(67.56)

1853(83.16)

 

12,296(30.12)

884(38.25)

 

Depression, n (%)

  

< 0.001

  

< 0.001

No

32,706(92.52)

1241(81.85)

 

13,480(35.86)

1095(51.41)

 

Yes

3047(7.48)

290(18.15)

 

24,113(64.14)

1035(48.59)

 

Fast glucose (mg/dL)

105.07 ± 0.28

118.39 ± 1.75

< 0.001

108.20 ± 31.58

113.60 ± 39.22

< 0.001

Hemoglobin (g/dL)

14.30 ± 0.02

13.85 ± 0.05

< 0.001

14.40 ± 2.22

14.54 ± 2.13

< 0.01

Triglyceride (mg/dL)

130.57 ± 1.14

144.99 ± 4.40

0.001

133.06 ± 111.57

140.19 ± 85.08

< 0.01

Total cholesterol (mg/dL)

195.72 ± 0.37

188.91 ± 1.47

< 0.001

193.22 ± 38.47

198.12 ± 38.61

< 0.001

HDL cholesterol (mg/dL)

53.30 ± 0.16

51.96 ± 0.58

0.02

51.36 ± 15.25

50.63 ± 14.77

0.05

LDL cholesterol (mg/dL)

115.43 ± 0.36

107.13 ± 1.72

< 0.001

116.25 ± 34.44

120.44 ± 35.90

< 0.001

C reactive protein (mg/dL)

0.41 ± 0.01

0.65 ± 0.03

< 0.001

2.30 ± 5.97

2.87 ± 7.01

< 0.01

eGFR (ml/min/1.73 m²)

95.13 ± 0.25

73.35 ± 0.70

< 0.001

97.19 ± 13.27

92.27 ± 15.13

< 0.001

  1. P-values from the t-test for continuous variables and P-values from Chi-square test for categorical variables.
  2. Abbreviations: CHARLS, China Health and Retirement Longitudinal Study; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NHANES, National Health and Nutrition Examination Survey.