Fig. 2

Association between plasma biomarkers, centiloid, and GM integrity. GBSS showing the correlations between FA (A), MD (B), and FW (C) and plasma biomarkers (NLF, GFAP, pTau217, and centiloid). Results are TFCE enhanced, reported at p < 0.01, FWE corrected. The green voxels indicate the gray matter skeleton used for statistical testing, and voxels with significant correlations (corrected p < 0.01) are shown in red to yellow. GBSS, gray matter based spatial statistics; GM, gray matter; FA, fractional anisotropy; MD, mean diffusivity; FW, free water, NfL, neurofilament light chain; GFAP, glial fibrillary acidic protein.