Fig. 4 | Scientific Reports

Fig. 4

From: Mapping Alzheimer’s disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures

Fig. 4

Diagram of mediation analyses among DTI metrics in WM, brain atrophy measures, and CDR-SOB. Mediation analyses were performed using DTI metrics as a predictor, brain atrophy measures as a mediator, and CDR-SOB as an outcome. Significance levels are follows: *p < 0.05, **p < 0.01, ***p < 0.001. FA, fractional anisotropy; MD, mean diffusivity; CDR-SOB, clinical dementia rating sum of boxes; WM, white matter.

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