Fig. 5
From: Exposure-inducible genes may contribute to missingness in RNAseq-based gene expression analyses
Modeling of the effect of exposure-sensitive genes on missingness. Each dot represents a sample, the orange horizontal bar shows the detection threshold, and the vertical green bar indicates samples/individuals with environmental exposure. The top 3 panels depict the situation with no environmental exposure, the middle panels show the situation when exposure increases the level of expression, and the bottom panels illustrate the situation when exposure suppresses gene expression. Normal conditions: the only source of missingness is borderline expressed genes (b). Environmental exposure that increases gene expression is present in half of the study population (green square). There are two sources of missingness: borderline expressed genes (e) and the genes that are not expressed under the normal conditions but are expressed in response to an environmental exposure (f). Environmental exposure that decreases gene expression is present in half of the study population (green square). There are two sources of missingness: borderline expressed genes (h) and the genes that are highly expressed under the normal conditions but are suppressed in response to an environmental exposure (g).
