Table 4 External Validation Results of ADNI’s top model on AIBL, using both full and common feature sets.

From: Alzheimer’s disease risk prediction using machine learning for survival analysis with a comorbidity-based approach

Model

Internal Validation

External Validation

Feature Set

C-index

Feature Set

C-index

Fast Random Survival Forest (Stage 1)

FS1 (all features)

0.84

FS1 (aligned AIBL)

0.73

Fast Random Survival Forest (Stage 2)

Common features only

0.79

Common features only

0.75

Fast Random Survival Forest (Sensitivity)

FS1

0.84

FS1 (multiple imputation)

0.77

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