Table 4 Candidate genes putatively selected by cross population EHH (XPEHH) statistical method affecting draught, milk, small and large stature traits in Zebu cattle.
Term | Database | p-value | Input | Summary of gene function |
|---|---|---|---|---|
Draught and dairy | ||||
cytokine-mediated signalling pathway | GO: BP | 0.004 | IFNAR1, IFNAR2, IFNGR2, IL10RB | Immune response, Reproduction, Milk production |
negative regulation of endopeptidase activity | GO: BP | 0.009 | SERPINB1, SERPINB9, SERPINB6 | Wound healing |
type I interferon signalling pathway | GO: BP | 0.037 | IFNAR1, IFNAR2 | Immune response |
Necroptosis | KEGG_PATHWAY | 0.010 | IFNAR1, IFNAR2, IFNGR2, RIPK1 | Immune response |
JAK-STAT signalling pathway | KEGG_PATHWAY | 0.019 | IFNAR1, IFNAR2, IFNGR2, IL10RB | Physiology, Growth, Immune response, |
Toll-like receptor signalling pathway | KEGG_PATHWAY | 0.044 | IFNAR1, IFNAR2, RIPK1 | Innate and adaptive immune response |
Natural killer cell mediated cytotoxicity | KEGG_PATHWAY | 0.048 | IFNAR1, IFNAR2, IFNGR2 | Immune response |
Small and large stature | ||||
Late endosome to vacuole transport via multivesicular body sorting pathway | GO: BP | 0.004 | CHMP4A, TMEM50A, TMEM50B | Physiology |
Regulation of heart rate | GO: BP | 0.014 | DRD2, MYH6, MYH7 | Physiology related to visceral muscle, changes in their contraction-relaxation cycle, in the maintenance of homeostasis in biological systems |
Visceral muscle development | GO: BP | 0.016 | MYH6, MYH7 | Physiology |
Regulation of heart growth | GO: BP | 0.032 | MYH6, MYH7 | Heart physiology through cycle of repetitive events that causes actin and myosin interaction |
Muscle filament sliding | GO: BP | 0.032 | MYH6, MYH7 | Regulation of molecular function |
Positive regulation of endopeptidase activity | GO: BP | 0.040 | MYH6, MYH7 | Physiology, harness the energy released from the breakdown of the phosphate bond and utilize it to perform other cellular reactions |
Regulation of ATPase activity | GO: BP | 0.040 | MYH6, MYH7 | Immune response |
Antigen processing and presentation of exogenous antigen | GO: BP | 0.040 | PSME1, PSME2 | Immune response |
Regulation of adaptive immune response | GO: BP | 0.040 | DUSP10, RIPK3 | Immune response |
Fertilization | GO: BP | 0.040 | REC8, CLIC4, TSSK4 | Reproduction and fertility |
Inorganic cation transmembrane transport | GO: BP | 0.048 | HTR3A, HTR3B | Reproduction |
Necroptosis | KEGG_PATHWAY | 0.002 | CHMP4A, IFNAR1, IFNAR2, IFNGR2, IRF9, RIPK3, RNF31 | Innate immune responses |
Proteasome | KEGG_PATHWAY | 0.005 | PSMB5, PSME1, PSME2, PSMB11 | related to antigen processing for appropriate immune responses, stress signalling, inflammatory responses, and apoptosis |
