Table 1 Clinicopathological parameters in all cohorts.
Characteristics | Training cohort (n = 143) | Validation cohort (n = 61) | P |
|---|---|---|---|
Gender, n(%) | 0.643 | ||
Male | 77(53.8%) | 35(57.4%) | |
Female | 66(46.2%) | 26(42.6%) | |
Age, n(%) | 0.948 | ||
< 60 | 64(44.8%) | 27(44.3%) | |
≥ 60 | 79(55.2%) | 34(55.7%) | |
HG, n(%) | 0.958 | ||
Well | 67(46.9%) | 28(45.9%) | |
Moderate | 44(30.8%) | 20(32.8%) | |
Poor | 32(22.4%) | 13(21.3%) | |
pT stage, n(%) | 0.891 | ||
T1 | 19(13.3%) | 10(16.4%) | |
T2 | 27(18.9%) | 13(21.3%) | |
T3 | 39(27.3%) | 15(24.6%) | |
T4 | 58(40.6%) | 23(37.7%) | |
pN stage, n(%) | 0.305 | ||
N0 | 83(58.0%) | 42(68.9%) | |
N1 | 42(29.4%) | 12(19.7%) | |
N2 | 18(12.6%) | 7(11.5%) | |
Smoking, n(%) | 0.841 | ||
No | 112(78.3%) | 47(77.0%) | |
Yes | 31(21.7%) | 14(23.0%) | |
Hypertension, n(%) | 0.722 | ||
No | 102(71.3%) | 42(68.9%) | |
Yes | 41(28.7%) | 19(31.1%) | |
Family history of cancer, n(%) | 0.618 | ||
No | 103(72.0%) | 46(75.4%) | |
Yes | 40(28.0%) | 15(24.6%) | |
CEA, n(%) | 0.418 | ||
Normal | 90(62.9%) | 42(68.9%) | |
Abnormal | 53(37.1%) | 19(31.1%) | |
CA242, n(%) | 0.763 | ||
Normal | 133(93.0%) | 56(91.8%) | |
Abnormal | 10(7.0%) | 5(8.2%) | |
CA724, n(%) | 0.992 | ||
Normal | 129(90.2%) | 55(90.2%) | |
Abnormal | 14(9.8%) | 6(9.8%) | |
CA199, n(%) | 1.000 | ||
Normal | 133(93.0%) | 57(93.4%) | |
Abnormal | 10(7.0%) | 4(6.6%) | |
Ki-67 level, n(%) | 0.158 | ||
Low | 10(7.0%) | 8(13.1%) | |
High | 133(93.0%) | 53(86.9%) | |
HIF-1α, n(%) | 0.071 | ||
Low | 60(42.0%) | 34(55.7%) | |
High | 83(58.0%) | 27(44.3%) | |
MSI, n(%) | 0.731 | ||
Low | 111(77.6%) | 46(75.4%) | |
High | 32(22.4%) | 15(24.6%) | |
VEGF, n(%) | 0.289 | ||
Low | 80(55.9%) | 39(63.9%) | |
High | 63(44.1%) | 22(36.1%) | |
LVI, n(%) | 0.847 | ||
Absent | 106(74.1%) | 46(75.4%) | |
Present | 37(25.9%) | 15(24.6%) | |
PNI, n(%) | 0.349 | ||
Absent | 122(85.3%) | 55(90.2%) | |
Present | 21(14.7%) | 6(9.8%) | |
Recurrence, n(%) | 0.258 | ||
No | 92(64.3%) | 47(77%) | |
Yes | 51(35.7%) | 14(23.0%) | |
Surgical procedure, n(%) | 0.802 | ||
Low anterior resection | 117(81.8%) | 49(80.3%) | |
Abdominoperineal resection | 26(18.2%) | 12(19.7%) | |
Adjuvant chemotherapy, n(%) | 0.505 | ||
No | 47(32.9%) | 23(37.7%) | |
Yes | 96(67.1%) | 38(62.3%) |
