Fig. 3 | Scientific Reports

Fig. 3

From: Targeting dendritic cell-specific TNFR2 improves skin and joint inflammation in a murine model of psoriatic arthritis

Fig. 3

Reduced expansion of conventional DC1 (cDC1) population in DC-TNFR2KO mice following MOS treatment. Flowcytometry plots of cDC1 and cDC2 populations in spleen cells from control and DC-TNFR2KO mice ± MOS. (A) representative figure showing the percentage of cDC1 and cDC2 cells among the splenocytes isolated from control or DC-TNFR2KO mice ± MOS. (B) Quantification of cDC1%. (C) Quantification of cDC2%. Data (n = 5 per group) represent means ± S.E, (D) (a) Quantification of CD80 expression in cDC1 (n = 3 per group) mean ± S.E.M. (b) Histogram of CD86 expression in cDC1, gMFI; Geometric Mean Fluorescent Intensity. (** p < 0.01, *** p < 0.001, ns = not significant). Tissue samples were collected on day 6 post-MOS.

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