Fig. 1 | Scientific Reports

Fig. 1

From: Refinement of the rat acetylcholine receptor-specific passive transfer myasthenia gravis model using subcutaneous injections: an update to the guidelines

Fig. 1

Progression of body weight and symptoms upon PTMG induction. mAb35 levels in serum at (A) 24 h and (B) at endpoint. (C) Overview of mean BW for each treatment group throughout the experiment. Error bars represent SEM. Daily BW measurements per experimental group at (D) 24 h and (E) at endpoint. Animals were clinically scored once per day for MG symptoms; (F) 24 h and (G) at endpoint. The grey circled data point is the misinjected animal in the mAb35 I.P. 20 ρmol 48 h group and has been excluded from statistical analysis. One way ANOVA with Bonferroni’s test was performed for statistical analysis. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, **** P ≤ 0.0001 vs. non-MG S.C.+ I.P.

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