Fig. 2 | Scientific Reports

Fig. 2

From: Refinement of the rat acetylcholine receptor-specific passive transfer myasthenia gravis model using subcutaneous injections: an update to the guidelines

Fig. 2

The effect of mAb35 injection route on muscle strength. Forelimb grip strength of treatment groups at (A) 24 h and (B) at endpoint and (C) overview of mean rack grabbing force during the experiment per treatment group at all time points from baseline to 72 h post-immunization. One symbol represents the average of five tasks. Errors bars represent SEM. (D) Proportion of animals that completed the hand climbing task at baseline, t = 2, 24, 48 and 72 h post-immunization. The grey circled data point is the misinjected animal and has been excluded from statistical analysis. One way ANOVA with Bonferroni test was performed for statistical analysis.***P ≤ 0.001, **** P ≤ 0.0001 vs. non-MG S.C. + I.P.

Back to article page