Fig. 5
Receiver Operating Characteristic (ROC) curve analysis of differentially regulated miRNAs in COVID-19 patients compared to healthy controls. ROC analysis was conducted using RNA sequencing data from 51 nasal swab samples (control: n = 13, infected: n = 38). (a) ROC curves for 12 upregulated and 2 down regulated known miRNAs showing FC ≥ ± 2 identified through RNA sequencing. (b) ROC curves of 4 novel miRNAs identified in this study. (c) ROC curves for previously reported circulating miRNAs validated using expression data from our cohort. (d) Combined ROC curves showing the improved discriminative power when multiple miRNAs were combined as biomarker panels. ROC curves were drawn for these reported miRNAs using read count expression data from our study. In all ROC plots, red and green lines represent predictive curves for upregulated and downregulated miRNAs, respectively; the dashed blue line indicates the random classifier (reference line), whereas orange line represents predictive curves for combined miRNAs. The Area Under the Curve (AUC) values and corresponding p-values are indicated for each miRNA.
