Table 1 Screening of various factors in the synthesis of quinoxalines by FA@-Fe2O3 nanohybrida.
From: Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds
Entry | Solvent | Temp. (oC) | Catalyst (mg) | Conversion% |
|---|---|---|---|---|
1 | H2O | 60 | 2 | 30 |
2 | EtOH | 60 | 2 | 100 (95%)b |
3 | S.F. | 60 | 2 | 20 |
4 | MeCN | 60 | 2 | 70 |
5 | EtOAc | 70 | 2 | 50 |
6 | EtOH | 25 | 2 | 60 |
7 | EtOH | 40 | 2 | 60 |
8 | EtOH | 50 | 2 | 80 |
9 | EtOH | 70 | 2 | 85 |
10 | EtOH | 60 | 3 | 90 |
11 | EtOH | 60 | 1 | 50 |
12 | EtOH | 60 | - | 30 |
aThe reactions were run using 4, 4’-dimethoxybenzil (0.125 mmol) and o-phenylenediamine (0.15 mmol) after 60 min. bIsolated yield. | ||||
