Fig. 6

Homology of the SCO1758, SCO0954, SCO4439, and SCO4440 proteins. (a) Alignment of SCO1758 with the prototype bacterial EngA GTPases55, showing two GTP-binding domains, the G-1, G-3, and G-4 motifs, and the P-loop characteristic of EngA GTPases. (b) Conserved domain and protein conservation of SCO0954. (c) Conserved domains and protein conservation of SCO4439 and SCO4440. Conserved domain database accession numbers are provided, along with the average similarity of the protein orthologues across six model Streptomyces species: S. lividans, S. avermitilis, S. venezuelae, S. scabies, S. griseus, and S. clavuligerus.