Table 1 Baseline characteristics of female overactive bladder patients in the daytime and nighttime dosing groups (n = 109).
Variables | Daytime (n = 52) | Nighttime (n = 57) | p† |
|---|---|---|---|
Age (years) | 60.6 ± 12.2 | 60.2 ± 12.0 | 0.85 |
Parity | 2.5 ± 1.1 | 2.3 ± 1.1 | 0.38 |
Body mass index (kg/m2) | 24.1 ± 5.5 | 25.6 ± 4.6 | 0.13 |
Systolic blood pressure (mmHg) | 132 ± 24 | 133 ± 15 | 0.97 |
Diastolic blood pressure (mmHg) | 76 ± 12 | 75 ± 11 | 0.68 |
Heart rate (beat per minute) | 75 ± 11 | 76 ± 11 | 0.52 |
USS (0–4) | 2.3 ± 1.2 | 2.1 ± 1.0 | 0.36 |
OABSS (0–15) | 6.8 ± 3.6 | 5.4 ± 2.6 | 0.02 |
OABSS Q2 (i.e., nocturia) (0–3) | 2.0 ± 0.9 | 2.0 ± 1.0 | 0.76 |
UDI-6 (0–18) | 7.5 ± 3.8 | 7.5 ± 3.8 | 0.99 |
IIQ-7 (0–21) | 8.1 ± 5.3 | 7.6 ± 5.4 | 0.63 |
Stress urinary incontinence | 8 (15) | 11 (19) | 0.62 |
Bladder oversensitivity | 36 (69) | 43 (75) | 0.47 |
Detrusor overactivity | 11 (21) | 5 (9) | 0.10 |
Urodynamic stress incontinence | 26 (50) | 24 (42) | 0.44 |
Pad weight (g) | 45 ± 70 | 69 ± 86 | 0.12 |
Qmax (mL/s) | 23 ± 13 | 27 ± 18 | 0.26 |
Voided volume (mL) | 276 ± 163 | 284 ± 132 | 0.76 |
Postvoid residual volume (mL) | 106 ± 79 | 96 ± 57 | 0.47 |
Strong desire to void (mL) | 291 ± 130 | 275 ± 92 | 0.48 |
PdetQmax (mmHg) | 40 ± 32 | 37 ± 22 | 0.52 |
MUCP (cmH2O) | 80 ± 34 | 83 ± 33 | 0.64 |
Voiding episodes (72 h) | |||
06:00–12:00 | 8.0 ± 3.6 | 9.4 ± 4.4 | 0.09 |
12:00–18:00 | 9.5 ± 4.4 | 10.2 ± 4.9 | 0.49 |
18:00–24:00 | 8.1 ± 4.3 | 8.8 ± 3.4 | 0.34 |
24:00–06:00 | 6.0 ± 3.7 | 5.5 ± 3.3 | 0.52 |
All day | 31.6 ± 11.5 | 33.9 ± 11.9 | 0.33 |
Urgency episodes (72 h) | |||
06:00–12:00 | 1.7 ± 2.0 | 3.2 ± 3.9 | 0.02 |
12:00–18:00 | 1.9 ± 2.7 | 3.2 ± 4.3 | 0.07 |
18:00–24:00 | 1.1 ± 1.7 | 2.4 ± 3.3 | 0.01 |
24:00–06:00 | 1.4 ± 2.4 | 1.8 ± 2.7 | 0.45 |
All day | 6.0 ± 7.1 | 10.6 ± 12.7 | 0.03 |
Incontinence episodes (72 h) | |||
06:00–12:00 | 0.3 ± 0.9 | 0.3 ± 0.7 | 0.84 |
12:00–18:00 | 0.6 ± 1.3 | 0.3 ± 0.6 | 0.13 |
18:00–24:00 | 0.4 ± 0.9 | 0.4 ± 0.8 | 0.95 |
24:00–06:00 | 0.5 ± 1.2 | 0.1 ± 0.5 | 0.04 |
All day | 1.8 ± 3.3 | 1.2 ± 1.8 | 0.22 |
Nocturia episodes (72 h)‡ | 6.4 ± 4.8 | 6.1 ± 4.2 | 0.79 |
Fluid intake (mL/72 h) | |||
06:00–12:00 | 1705 ± 851 | 1712 ± 1023 | 0.97 |
12:00–18:00 | 1631 ± 698 | 1492 ± 971 | 0.43 |
18:00–24:00 | 1122 ± 846 | 1266 ± 846 | 0.41 |
24:00–06:00 | 560 ± 537 | 378 ± 468 | 0.08 |
All day | 4609 ± 2263 | 4574 ± 2511 | 0.94 |
Total voided volume (mL/72 h) | |||
06:00–12:00 | 1429 ± 822 | 1427 ± 730 | 0.99 |
12:00–18:00 | 1558 ± 777 | 1527 ± 971 | 0.86 |
18:00–24:00 | 1371 ± 835 | 1422 ± 1192 | 0.80 |
24:00–06:00 | 1243 ± 853 | 1167 ± 858 | 0.65 |
All day | 5602 ± 2070 | 5488 ± 2389 | 0.80 |
Voided volume per micturition (mL) | |||
06:00–12:00 | 191 ± 91 | 161 ± 88 | 0.09 |
12:00–18:00 | 179 ± 103 | 160 ± 96 | 0.35 |
18:00–24:00 | 195 ± 134 | 163 ± 131 | 0.23 |
24:00–06:00 | 234 ± 138 | 235 ± 138 | 0.97 |
