Fig. 4 | Scientific Reports

Fig. 4

From: Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis

Fig. 4

GBXZD alleviated renal pathological damage in UUO rats. (a) HE staining showed that GBXZD decreased inflammatory cell infiltration and ameliorated tubular injury relative to the UUO model rats. (b) Masson staining showed that GBXZD significantly reduced the deposition of collagen fibrillar protein in the kidneys of UUO rats. (c) GBXZD reduced the ratio of obstructed kidney to body weight in UUO rats. (d–E) GBXZD reduced blood urea nitrogen and serum creatinine levels in UUO rats. (f) Comparison of collagen area ratio based on Masson staining. *p < 0.05 vs. Model group, **p < 0.001 vs. Model group, ***p < 0.001 vs. Model group, ns for p > 0.05 vs. Model group.

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