Fig. 8 | Scientific Reports

Fig. 8

From: UPLC-Q-TOF/MS, network pharmacology, molecular docking, and experimental validation to explore the mechanisms of toad clothing on rheumatoid arthritis

Fig. 8

Molecular docking heat map analysis and results of the lowest binding energy in each target with the selected bioactive constituent of toad clothing. (A) Heat map analysis of molecular docking of core constituents to core targets;(B) resibufogenin, EGFR, −9.8 kcal/mol; arenobufagin, EGFR, −9.8 kcal/mol; cinobufagin, JAK2, −9.7 kcal/mol; resibufogenin, PIK3CA, −8.3 kcal/mol. EGFR, epidermal growth factor receptor; JAK2, Janus Kinase 2; PIK3CA, hosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.

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