Table 2 Eight core target genes of Rheumatoid Arthritis were treated with toad clothing.

From: UPLC-Q-TOF/MS, network pharmacology, molecular docking, and experimental validation to explore the mechanisms of toad clothing on rheumatoid arthritis

Gene name

BC

CC

DC

EGFR

993.887

0.024

37

STAT3

3937.288

0.024

34

AKT1

1858.077

0.024

34

PIK3CB

563.138

0.024

34

PIK3CD

471.788

0.024

33

PIK3CA

1631.014

0.024

30

HSP90AA1

1922.020

0.024

28

JAK2

487.031

0.024

22

  1. BC, betweenness centrality; CC, closeness centrality; DC, degree centrality; EGFR, epidermal growth factor receptor; STAT3, signal transducer and activator of transcription 3; AKT1, AKT Serine/Threonine Kinase 1; PIK3CB, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; PIK3CD Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; PIK3CA, hosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; HSP90AA1, heat shock protein family a member 1; JAK2, Janus Kinase 2.
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