Table 4 Multivariable Cox regression for bloodstream infection in liver transplant recipients.

From: Immunoglobulin G dynamics and outcomes of hypogammaglobulinemia in liver transplant recipients

 

Univariable analysis

Multivariable analysis

 

HR (95% CI)

p-value

HR (95% CI)

p-value

Age, years

1.00 (0.98–1.02)

0.907

  

Male sex

0.64 (0.40–1.01)

0.055

  

Underlying disease

    

Alcoholic

0.85 (0.51–1.39)

0.511

  

Viral hepatitis

1.10 (0.68–1.77)

0.709

  

Hypertension

0.58 (0.29–1.14)

0.115

  

Diabetes

1.10 (0.68–1.77)

0.710

  

Cardiovascular disease

1.41 (0.72–2.74)

0.314

  

HCC

1.53 (0.92–2.55)

0.100

  

High MELD

1.76 (1.11–2.80)

0.017

1.49 (0.91–2.44)

0.116

Donor age, years

1.01 (1.00–1.03)

0.087

  

Donor sex, male

1.19 (0.73–1.93)

0.494

  

Donor BMI, kg/m2

1.09 (1.01–1.19)

0.035

1.10 (1.01–1.20)

0.029

ABO incompatibility

0.82 (0.37–1.81)

0.626

  

Living donor

0.66 (0.40–1.07)

0.094

  

Rejection

2.28 (1.24–4.20)

0.008

2.51 (1.32–4.78)

0.005

Desensitization

    

Rituximab

0.84 (0.40–1.77)

0.655

0.70 (0.31–1.57)

0.380

Plasmapheresis

0.89 (0.43–1.87)

0.760

  

Surgery time, hr

1.06 (0.94–1.20)

0.326

  

Cold ischemia time, hr

1.09 (0.99–1.21)

0.087

  

RBC transfusion, pack

1.05 (1.02–1.08)

0.001

1.05 (1.01–1.09)

0.007

Pre-LT HGG

2.15 (0.89–5.23)

0.090

  

Post-LT HGG

2.19 (1.08–4.45)

0.030

1.46 (0.53–4.06)

0.463

  1. Post-LT HGG was assessed at postoperative 1 month. Post-LT HGG and rejection were used as time-varying variables. HGG was defined as a measured IgG level of < 700 mg/dL7.
  2. BMI, body mass index; CI, confidence interval; HCC, hepatocellular carcinoma; HGG, Hypogammaglobulinemia; HR, hazard ratio; LT, liver transplantation; MELD, model for end-stage liver disease; RBC, red blood cell.