Fig. 4 | Scientific Reports

Fig. 4

From: GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice

Fig. 4

The overexpression of GDNF counteracted the impact of α-syn aggregation on protein expression levels in both the VTA and NAc. (A-D) WB analysis of p-α-syn, GDNF and TH in the VTA (n = 5). (E-I) WB analysis of SNAP-25, PSD95, D2R and D1R in the NAc (n = 5). Data: Mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 (one-way ANOVA with Tukey’s test).

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