Fig. 5 | Scientific Reports

Fig. 5

From: GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice

Fig. 5

The overexpression of GDNF ameliorated the compromised DA transmission from the VTA to the NAc caused by α-syn aggregation. (A) Experimental timeline. (B) The results for the localization of the cis-tracer virus (green) in both the VTA and NAc of mice (scale bars: 100/200/500 µm), as well as the corresponding statistic diagram (C) (n = 6). (D-F) GAD67 (red) and SYN (green) co-localization in the NAc (scale bars: 100 μm), as well as the corresponding statistic diagram (G) (n = 6). Data: Mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 (one-way ANOVA with Tukey’s test).

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