Fig. 6 | Scientific Reports

Fig. 6

From: GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice

Fig. 6

The inhibition of D2-MSN in the NAc can improved depression-like behavior induced by α-syn aggregation. (A) Experimental timeline. (B) The representative diagram of the chemical genetic virus (red) in the NAc (scale bar = 200 μm). The statistic diagram for self-comparison before and after intraperitoneal injection in the OFT (C-E), TST (F) and FST (G) (n = 6, Data: Mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001) (Paired-samples t-test). The statistic diagram for comparative results between different groups after intraperitoneal injection in the OFT (H-J), TST (K) and FST (L) (n = 6, Data: Mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001) (one-way ANOVA with Tukey’s test).

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