Fig. 5 | Scientific Reports

Fig. 5

From: Tenofovir attenuates cytokine storm and bronchiolar damage in a mouse model of bleomycin-induced acute lung injury

Fig. 5

Decreased levels of inflammatory markers and changes in expression levels of angiotensin converting enzymes in BLM-challenged male and female mice pretreated with TDF. (A) Lung tissue mRNA expression of proinflammatory (Tnfα, Il1β, Il10 and Il6) and profibrotic (Tgfβ) markers. (B) Serum protein levels of IL6 determined by ELISA. (C) Ace and Ace2 mRNA levels were determined by qPCR. n = 5–6 mice per group. Data are expressed as mean ± SEM. *p < 0.05; **p < 0.01 (Mann-Whitney U- or Student´s t-tests).

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