Table 1 Baseline characteristics of the study population.

From: Time-resolved fluoroimmunoassay improves sensitivity in the diagnosis of primary membranous nephropathy with low phospholipase A2 receptor antibody titer

Characteristics

Overall (n = 175)

PMN (n = 91)

Non-PMN (n = 84)

P-value

Male (%)

105 (60.0%)

59 (64.8%)

46 (54.8%)

0.179

Age (years)

49 (33,60)

53 (39,64)

41 (31,56)

0.001

PLA2R-Ab (RU/ml)

4.85 (2.88,9.88)

6.77 (3.66,13.0)

3.42 (2.30,6.83)

 < 0.001

Urinary Protein (g/24 h)

3.06 (1.46,5.22)

3.77 (2.55,5.90)

2.07 (1.14,4.11)

0.053

serum albumin (g/l)

33.7 ± 7.05

31.0 ± 5.42

36.5 ± 7.51

 < 0.001

Uric Acid (μmol/l)

391 ± 106

396 ± 90.5

386 ± 121

0.529

BUN (mmol/l)

5.40 (4.30,7.10)

4.90 (4.10,5.95)

6.15 (4.70,8.10)

 < 0.001

Scr (μmol/l)

78 (63,106)

65 (59,80)

106 (77,143)

 < 0.001

CysC (mg/l)

1.06 (0.88,1.32)

0.95 (0.82,1.17)

1.18 (0.97,1.79)

 < 0.001

HGB (g/l)

135 ± 22.8

142 ± 18.3

127 ± 24.8

 < 0.001

eGFR (ml/min/1.73m2)

96(64,110)

102 (93,112)

70(42,100)

 < 0.001

FBG (mmol/l)

4.8 (4.3,5.4)

4.9 (4.5,5.4)

4.5(4.0,5.2)

0.066

HbA1c (%)

5.6 (5.3,6.2)

5.6 (5.3,6.3)

5.6 (5.3,6.1)

0.393

TC (mmol/l)

5.52 (4.57,7.12)

6.07 (5.18M7.78)

4.89 (3.84,6.10)

 < 0.001

TG (mmol/l)

1.79 (1.20,2.43)

1.93 (1.38,2.63)

1.54 (1.10,2.34)

0.260

HDL(mmol/l)

1.14 (0.98,1.42)

1.18 (1.02,1.42)

1.07 (0.90,1.41)

0.067

LDL (mmol/l)

3.40 (2.48,4.48)

3.79 (3.04,5.03)

2.90 (2.04,3.75)

 < 0.001

ALT (U/l)

15 (11,22)

17 (12,22)

14(10,21)

0.687

AST (U/l)

20 (16,26)

22 (17,27)

18 (16,24)

0.132

TBIL (μmol/l)

10.3 (7.80,13.4)

10.2 (7.85,13.8)

10.4 (7.80,12.9)

0.545

DBIL (μmol/l)

1.00 (0.60,1.70)

0.80 (0.50,1.55)

1.10 (0.70,1.70)

0.153

IgG (mg/ml)

9.09 (6.60,12.4)

7.34 (5.88,9.44)

11.9 (8.78,14.5)

 < 0.001

IgA (mg/ml)

2.70 (1.97,3.46)

2.39 (1.79,3.04)

3.09 (2.47,3.99)

 < 0.001

IgM (mg/ml)

1.04 (0.78,1.44)

1.08 (0.79,1.44)

1.02 (0.72,1.42)

0.800

IgE (IU/ml)

81.9 (22.1,197)

91.0 (28.0,188)

63.3 (19.8,267)

0.164

C3 (mg/ml)

0.99 (0.86,1.12)

1.02 (0.89,1.12)

0.95 (0.84,1.11)

0.043

C4 (mg/ml)

0.25 (0.21,0.31)

0.27 (0.22,0.32)

0.24 (0.19,0.29)

0.022

PLT (× 109/l)

248 ± 64.0

246 ± 62.1

249 ± 66.3

0.745

Fib (g/l)

3.62 (3.14,4.32)

3.76 (3.41,4.40)

3.38 (2.91,4.14)

0.214

D-dimer (μg/ml)

0.17 (0.11,0.30)

0.22 (0.15,0.34)

0.11 (0.11,0.23)

0.856

ESR (mm/h)

23.0 (10.0,40.0)

25.0 (14.5,37.5)

16.0 (7.00,47.8)

0.723

CRP (mg/dl)

0.21 (0.16,0.40)

0.20 (0.16,0.34)

0.23 (0.17,0.52)

0.016

  1. PMN, primary membrane nephropathy; BUN, blood urea nitrogen; Scr, serum creatinine; HGB, hemoglobin; eGFR, estimated glomerular filtration rate; FBG, fasting blood glucose; TC, total cholesterol; TG, triglyceride; HDL, High-density lipoprotein; LDL, low-density lipoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, Direct bilirubin; PTL, platelet; Fib, fibrinogen; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.
  2. P-values < 0.05 are in bold.
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