Fig. 2 | Scientific Reports

Fig. 2

From: Single-cell transcriptomic analysis of blood and bronchoalveolar lavage fluid in progressive fibrosing interstitial lung diseases

Fig. 2

Subtypes of mononuclear myeloid cells and B/plasma cells in bronchoalveolar lavage fluid (BALF). a) Comparative analysis of the proportions of mononuclear myeloid cells in BALF between patients with non-progressive fibrosing (PF) interstitial lung disease (ILD) and patients with PF-ILD. (b) Uniform manifold approximation and projection (UMAP) visualization of B/plasma cells in BALF. Five clusters were identified. Each cluster is represented by a unique color, number, and cell type. (c) Dot plots show the top marker genes per cluster. (d) Comparative analysis of the proportions of B/plasma cells between non-PF-ILD patients and PF-ILD patients. Abbreviations: PF: progressive fibrosing; ILD: interstitial lung disease; CXCL: C-X-C motif chemokine ligand; CCL: C-C motif chemokine ligand; NEAT: nuclear enriched abundant transcript; FABP: fatty acid binding protein; APOC: apolipoprotein C; SPP: secretory pathway peptidase; PPARG: peroxisome proliferator-activated receptor gamma; DC: dendritic cell

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