Table 2 BCVA and other secondary outcomes.

From: A double-blind, randomized controlled pilot study comparing the safety of intracameral levofloxacin and intracameral cefazolin in patients undergoing cataract surgery

Outcome

Levofloxacin (0.1 ml/0.5 mg)

Cefazolin (0.1 ml/1 mg)

Group difference*

n

n

Ratio/mean (95% CI)

P value

BCVA, median (IQR)

Baseline

25

0.32 (0.20, 0.48)

25

0.28 (0.18, 0.48)

  

Day 7

25

0.10 (0.02, 0.14)

25

0.08 (0.02, 0.18)

1.24 (0.65, 2.38)

0.51

Month 1

25

0.02 (0.00, 0.04)

25

0.02 (0.00, 0.04)

1.28 (0.71, 2.34)

0.40

Month 3

25

0.02 (0.00, 0.06)

25

0.00 (0.00, 0.02)

1.36 (0.75, 2.49)

0.30

CFT, median (IQR)

Baseline

20

267 (246, 376)

23

269 (252, 290)

  

Month 1

25

267 (248, 283)

25

271 (257, 294)

0.99 (0.92, 1.07)

0.82

Month 3

25

270 (258, 279)

25

278 (261, 300)

1.00 (0.91, 1.10)

0.94

IOP, mean ± SD

Baseline

25

14.4 ± 2.6

25

13.7 ± 2.6

  

Day 7

25

13.5 ± 2.3

25

12.8 ± 3.0

0.5 (–1.0, 2.0)

0.52

Month 1

25

13.1 ± 2.6

25

12.9 ± 2.6

–0.1 (–1.4, 1.2)

0.88

Month 3

25

12.6 ± 2.8

25

12.3 ± 2.4

0.1 (–1.4, 1.5)

0.93

CCT, mean ± SD

Baseline

23

549 ± 31

25

564 ± 37

  

Month 1

23

578 ± 31

25

585 ± 44

8 (–10, 25)

0.37

Month 3

24

563 ± 34

25

569 ± 43

7 (–10, 24)

0.39

Cell density, mean ± SD

Baseline

25

2525 ± 441

25

2611 ± 428

  

Month 1

25

1779 ± 518

25

1907 ± 650

–113 (–450, 223)

0.50

Month 3

25

1838 ± 526

25

1984 ± 664

–120 (–458, 217)

0.48

  1. *Group difference for BCVA and CFT is displayed as a ratio (95% CI). The ratio was calculated as outcome for levofloxacin divided by outcome for cefazolin. Group difference for IOP, CCT, and cell density is displayed as a mean (95% CI). The mean difference was calculated as outcome for levofloxacin minus outcome for cefazolin. Differences were adjusted for values at baseline. This feasibility study may be under-powered to detect modest safety difference because no a-priori sample size calculation was performed. BCVA=best-corrected visual acuity; CCT=central corneal thickness; CFT=central foveal thickness; IOP=intraocular pressure; IQR=interquartile range.
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