Fig. 2

PKS type I gene cluster located on the giant linear plasmid pSB1: evolutionary relations with the stambomycin gene cluster of S. ambofaciens. PKS genes are numbered according to the biosynthetic order predicted for pSB1 PKS BGC by antiSMASH and experimentally verified for stambomycins. Homologous PKS genes are shaded and marked with dotted lines and those designated in blue font are unique for each cluster. Stb _PKS – PKSI of the stambomycin BGC; Sbam_PKS – PKSI of the pSB1-licated BGC in S. bambergiensis.