Fig. 5
From: IL6/STAT3 induced GRWD1 mediates aerobic glycolysis via P53/GLUT1 signal axis in colon carcinoma
The effect of GRWD1 on GLUT1 expression. (A) The correlation between GRWD1 and SLC2A1, PGK1, and G6PD mRNA expression was analyzed using the TCGA databases. qPCR analysis of GRWD1 knockdown (B) and overexpression (C) on GLUT1, PGK1 and G6PD mRNA level. qPCR analysis of GLUT1 mRNA expression following IL-6 (30 μg/L) treatment for 4 h in GRWD1 knockdown (D) and overexpression (E) cells. (F) The four groups of GRWD1 and GLUT1 expression in the TCGA-COADREAD cohort were represented on the left. The Kaplan–Meier survival curves showed the PFS (on the middle) and DFS (on the right) by the expression levels of GRWD1 and GLUT1.
