Table 2 Unadjusted and Adjusted Cox proportional hazard regression analysis of death stratified for preoperative as well as pathological and postoperative factors.
Variable | Unadjusted HR | Adjusted HR | P-value |
|---|---|---|---|
Preoperative factors | |||
Age > 50 years | 0.93 (0.38, 2.30) | 0.42 (0.11, 1.58) | 0.20 |
Postmenopausal at diagnosis | 1.07 (0.38, 2.97) | – | – |
T stage | |||
Tis-T1 | 1 | 1 | |
T2 | 0.48 (0.03, 7.75) | 0.37 (0.02, 6.62) | 0.50 |
T3 | 1.48 (0.17, 12.8) | 3.09 (0.29, 33.0) | 0.35 |
T4 | 0.88 (0.11, 6.82) | 0.96 (0.11, 8.56) | 0.97 |
N stage | |||
N0–N1 | 1 | 1 | |
N2 | 1.74 (0.68, 4.42) | 3.69 (1.11, 12.3) | 0.03* |
N3 | 2.44 (0.30, 19.8) | 2.31 (0.24, 22.1) | 0.47 |
Site of metastasis | |||
Liver | 1.82 (0.67, 4.95) | 5.30 (1.28, 22.0) | 0.02* |
Lung | 0.82 (0.31, 2.16) | – | – |
Bone | 1.24 (0.47, 3.26) | 3.1 (0.76, 12.6) | 0.11 |
Delay in surgery from diagnosis | |||
Within one month | 1 | – | – |
Within one month and one year | 0.93 (0.20, 4.32) | ||
After one year | 0.40 (0.07, 2.29) | ||
Chemotherapy | 0.64 (0.09, 4.57) | – | – |
Pathological and postoperative factors | |||
pT stage | |||
T0–T1 | 1 | – | – |
T2 | 2.53 (0.52, 12.3) | ||
T3 | 3.20 (0.54, 19.0) | ||
T4 | 1.75 (0.28, 11.2) | ||
pN stage | |||
N0 | 1 | 1 | – |
N1 | 0.80 (0.18, 3.40) | 0.51 (0.05, 4.78) | 0.55 |
N2 | 2.29 (.61, 8.57) | 23.4 (1.33, 408) | 0.03* |
N3 | 3.74 (.93, 15.1) | 4.28 (0.59, 31.2) | 0.15 |
IDC | 1.16 (0.26, 5.18) | – | 0.84 |
Grade | |||
Low | 1 | 1 | |
Moderate | 0.83 (0.16, 4.14) | 60.0 (0.83, 4324) | 0.06 |
High | 0.25 (0.04, 1.51) | 2.76 (0.23, 32.5) | 0.42 |
Lymphovascular invasion | 1.62 (0.59, 4.43) | – | – |
Tumor biology | |||
Triple positive | 1 | 1 | |
HR + ve | 0.90 (0.27, 2.92) | 0.025 (0.001, 0.82) | 0.04* |
HER2 enriched | 1.02 (0.22, 4.68) | 0.10 (0.004, 2.87) | 0.18 |
Triple negative | 0.87 (0.15, 4.94) | 0.05 (0.001, 2.46) | 0.13 |
Adjuvant radiation | 0.80 (0.17, 3.77) | 0.49 (0.03, 8.92) | 0.63 |
