Fig. 4

Predictive associations of genetic biomarkers and PFS—multivariate analyses. *The analysis was conducted in the TMB-evaluable population (N = 102). †Frequency in each treatment group. Deviations from PH assumption of exposures were not assessed. aHR, adjusted HR; CI, confidence interval; CT, chemotherapy, CT-IO, chemo-immunotherapy; HR, hazard ratio; int-aHR, interaction-aHR; IO, immunotherapy; Mut, mutant; PFS, progression-free survival; TMB-H, tumor mutational burden high; TT, targeted therapy; WT, wild-type.